Increased CCAAT enhancer-binding protein epsilon (C/EBPepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia. [electronic resource]
Producer: 20060613Description: 10745-51 p. digitalISSN:- 0021-9258
- Animals
- Apoptosis
- Blotting, Western
- CCAAT-Enhancer-Binding Proteins -- biosynthesis
- Cell Cycle
- Cell Differentiation
- Cell Line
- Cell Proliferation
- Cell Survival
- DNA -- metabolism
- DNA Fragmentation
- DNA-Binding Proteins -- genetics
- Gene Expression Regulation
- Genetic Vectors
- Granulocyte Colony-Stimulating Factor -- metabolism
- Granulocytes -- metabolism
- Interleukin-3 -- metabolism
- Mice
- Mutation
- Myeloid Cells -- metabolism
- Neutropenia -- congenital
- Protein Structure, Tertiary
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- RNA, Messenger -- metabolism
- Signal Transduction
- Time Factors
- Transcription Factors -- genetics
- Transcription, Genetic
- Transfection
- Up-Regulation
- Zinc Fingers
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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