Increased CCAAT enhancer-binding protein epsilon (C/EBPepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia.

Zhuang, Dazhong

Increased CCAAT enhancer-binding protein epsilon (C/EBPepsilon) expression and premature apoptosis in myeloid cells expressing Gfi-1 N382S mutant associated with severe congenital neutropenia. [electronic resource] - The Journal of biological chemistry Apr 2006 - 10745-51 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

0021-9258

10.1074/jbc.M510924200 doi


Animals
Apoptosis
Blotting, Western
CCAAT-Enhancer-Binding Proteins--biosynthesis
Cell Cycle
Cell Differentiation
Cell Line
Cell Proliferation
Cell Survival
DNA--metabolism
DNA Fragmentation
DNA-Binding Proteins--genetics
Gene Expression Regulation
Genetic Vectors
Granulocyte Colony-Stimulating Factor--metabolism
Granulocytes--metabolism
Interleukin-3--metabolism
Mice
Mutation
Myeloid Cells--metabolism
Neutropenia--congenital
Protein Structure, Tertiary
Proto-Oncogene Proteins c-bcl-2--metabolism
RNA, Messenger--metabolism
Signal Transduction
Time Factors
Transcription Factors--genetics
Transcription, Genetic
Transfection
Up-Regulation
Zinc Fingers