Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development. [electronic resource]
Producer: 20060213Description: 605-16 p. digitalISSN:- 0270-7306
- Alleles
- Amino Acid Motifs
- Animals
- Cell Line
- Embryo Loss
- Fetal Development -- physiology
- Furin -- metabolism
- Gene Expression
- Kupffer Cells -- metabolism
- Liver -- metabolism
- Low Density Lipoprotein Receptor-Related Protein-1
- Lysosomes -- metabolism
- Mice
- Mice, Mutant Strains
- Mutagenesis, Insertional
- Mutation
- Phenotype
- Protein Subunits -- genetics
- Receptors, LDL -- genetics
- Recombinases -- genetics
- Tumor Suppressor Proteins -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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