Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development.

Roebroek, Anton J M

Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development. [electronic resource] - Molecular and cellular biology Jan 2006 - 605-16 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0270-7306

10.1128/MCB.26.2.605-616.2006 doi


Alleles
Amino Acid Motifs
Animals
Cell Line
Embryo Loss
Fetal Development--physiology
Furin--metabolism
Gene Expression
Kupffer Cells--metabolism
Liver--metabolism
Low Density Lipoprotein Receptor-Related Protein-1
Lysosomes--metabolism
Mice
Mice, Mutant Strains
Mutagenesis, Insertional
Mutation
Phenotype
Protein Subunits--genetics
Receptors, LDL--genetics
Recombinases--genetics
Tumor Suppressor Proteins--genetics