Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure. [electronic resource]
Producer: 20060222Description: 3633-43 p. digitalISSN:- 1524-4539
- Animals
- Antioxidants -- pharmacology
- Antipyrine -- analogs & derivatives
- Calcium -- metabolism
- Cardiac Pacing, Artificial
- Dogs
- Edaravone
- Heart Failure -- drug therapy
- Heart Ventricles
- Muscle Cells -- cytology
- Nitric Oxide Donors -- pharmacology
- Oxidative Stress -- drug effects
- Protein Structure, Tertiary
- Ryanodine Receptor Calcium Release Channel -- chemistry
- Sarcoplasmic Reticulum -- drug effects
- Tacrolimus Binding Protein 1A -- metabolism
- Treatment Outcome
- Ventricular Remodeling -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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