Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure.

Yano, Masafumi

Correction of defective interdomain interaction within ryanodine receptor by antioxidant is a new therapeutic strategy against heart failure. [electronic resource] - Circulation Dec 2005 - 3633-43 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1524-4539

10.1161/CIRCULATIONAHA.105.555623 doi


Animals
Antioxidants--pharmacology
Antipyrine--analogs & derivatives
Calcium--metabolism
Cardiac Pacing, Artificial
Dogs
Edaravone
Heart Failure--drug therapy
Heart Ventricles
Muscle Cells--cytology
Nitric Oxide Donors--pharmacology
Oxidative Stress--drug effects
Protein Structure, Tertiary
Ryanodine Receptor Calcium Release Channel--chemistry
Sarcoplasmic Reticulum--drug effects
Tacrolimus Binding Protein 1A--metabolism
Treatment Outcome
Ventricular Remodeling--drug effects