Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. [electronic resource]
Producer: 20060206Description: 3484-93 p. digitalISSN:- 0021-9738
- Agouti-Related Protein
- Alleles
- Animals
- Blood Glucose -- metabolism
- Body Composition
- Body Weight
- Cold Temperature
- DNA, Complementary -- metabolism
- Diabetes Mellitus -- genetics
- Female
- Fertility
- Gene Expression Regulation
- Genetic Therapy -- methods
- Genotype
- Glucose -- metabolism
- Homeostasis
- Homozygote
- Hypothalamus -- pathology
- In Situ Hybridization
- Infertility -- genetics
- Infertility, Female -- therapy
- Infertility, Male -- therapy
- Insulin -- metabolism
- Intercellular Signaling Peptides and Proteins
- Male
- Mice
- Mice, Transgenic
- Neurons -- metabolism
- Neuropeptide Y -- genetics
- Obesity -- genetics
- Peptides -- chemistry
- Phenotype
- Phosphopyruvate Hydratase -- genetics
- Polymerase Chain Reaction
- Pro-Opiomelanocortin -- genetics
- Promoter Regions, Genetic
- Protein Isoforms
- Proteins -- genetics
- Rats
- Receptors, Cell Surface -- genetics
- Receptors, Leptin
- Signal Transduction
- Synapsins -- genetics
- Time Factors
- Tissue Distribution
- Transgenes
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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