Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes.

de Luca, Carl

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. [electronic resource] - The Journal of clinical investigation Dec 2005 - 3484-93 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

0021-9738

10.1172/JCI24059 doi


Agouti-Related Protein
Alleles
Animals
Blood Glucose--metabolism
Body Composition
Body Weight
Cold Temperature
DNA, Complementary--metabolism
Diabetes Mellitus--genetics
Female
Fertility
Gene Expression Regulation
Genetic Therapy--methods
Genotype
Glucose--metabolism
Homeostasis
Homozygote
Hypothalamus--pathology
In Situ Hybridization
Infertility--genetics
Infertility, Female--therapy
Infertility, Male--therapy
Insulin--metabolism
Intercellular Signaling Peptides and Proteins
Male
Mice
Mice, Transgenic
Neurons--metabolism
Neuropeptide Y--genetics
Obesity--genetics
Peptides--chemistry
Phenotype
Phosphopyruvate Hydratase--genetics
Polymerase Chain Reaction
Pro-Opiomelanocortin--genetics
Promoter Regions, Genetic
Protein Isoforms
Proteins--genetics
Rats
Receptors, Cell Surface--genetics
Receptors, Leptin
Signal Transduction
Synapsins--genetics
Time Factors
Tissue Distribution
Transgenes