Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. [electronic resource]
Producer: 20060307Description: 2012-23 p. digitalISSN:- 0021-9258
- Adrenergic Uptake Inhibitors -- pharmacology
- Amino Acid Sequence
- Animals
- Antidepressive Agents -- pharmacology
- Binding Sites
- Binding, Competitive
- Blotting, Western
- Cadmium -- chemistry
- Cell Line
- Cell Membrane -- metabolism
- Citalopram -- pharmacology
- Clomipramine -- pharmacology
- Cocaine -- analogs & derivatives
- Cysteine -- chemistry
- Dopamine Uptake Inhibitors -- pharmacology
- Fluoxetine -- analogs & derivatives
- HeLa Cells
- Humans
- Immunoprecipitation
- Isoleucine -- chemistry
- Kinetics
- LLC-PK1 Cells
- Mazindol -- pharmacology
- Methionine -- chemistry
- Mice
- Models, Chemical
- Molecular Sequence Data
- Mutation
- N-Methyl-3,4-methylenedioxyamphetamine -- chemistry
- Nomifensine -- pharmacology
- Protein Binding
- Protein Structure, Tertiary
- Protein Transport
- Radiopharmaceuticals -- pharmacology
- Receptors, Serotonin -- chemistry
- Serotonin -- chemistry
- Selective Serotonin Reuptake Inhibitors -- pharmacology
- Species Specificity
- Stereoisomerism
- Substrate Specificity
- Tyrosine -- chemistry
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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