Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.

Henry, L Keith

Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants. [electronic resource] - The Journal of biological chemistry Jan 2006 - 2012-23 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M505055200 doi


Adrenergic Uptake Inhibitors--pharmacology
Amino Acid Sequence
Animals
Antidepressive Agents--pharmacology
Binding Sites
Binding, Competitive
Blotting, Western
Cadmium--chemistry
Cell Line
Cell Membrane--metabolism
Citalopram--pharmacology
Clomipramine--pharmacology
Cocaine--analogs & derivatives
Cysteine--chemistry
Dopamine Uptake Inhibitors--pharmacology
Fluoxetine--analogs & derivatives
HeLa Cells
Humans
Immunoprecipitation
Isoleucine--chemistry
Kinetics
LLC-PK1 Cells
Mazindol--pharmacology
Methionine--chemistry
Mice
Models, Chemical
Molecular Sequence Data
Mutation
N-Methyl-3,4-methylenedioxyamphetamine--chemistry
Nomifensine--pharmacology
Protein Binding
Protein Structure, Tertiary
Protein Transport
Radiopharmaceuticals--pharmacology
Receptors, Serotonin--chemistry
Serotonin--chemistry
Selective Serotonin Reuptake Inhibitors--pharmacology
Species Specificity
Stereoisomerism
Substrate Specificity
Tyrosine--chemistry