Loss of Sp1 function via inhibitory phosphorylation in antifolate-resistant human leukemia cells with down-regulation of the reduced folate carrier. [electronic resource]
Producer: 20060207Description: 708-15 p. digitalISSN:- 0006-4971
- 1-Methyl-3-isobutylxanthine -- pharmacology
- Alkaline Phosphatase -- metabolism
- Binding Sites
- Cyclic AMP -- metabolism
- Cyclic AMP-Dependent Protein Kinases -- metabolism
- Cyclic GMP -- analogs & derivatives
- Down-Regulation
- Drug Resistance, Neoplasm
- Electrophoretic Mobility Shift Assay
- Enzyme Inhibitors -- pharmacology
- Folic Acid Antagonists -- pharmacology
- GC Rich Sequence
- Humans
- Leukemia, T-Cell -- drug therapy
- Luciferases -- metabolism
- Membrane Transport Proteins -- genetics
- Nuclear Proteins
- Okadaic Acid -- pharmacology
- Phosphodiesterase Inhibitors -- pharmacology
- Phosphoprotein Phosphatases -- antagonists & inhibitors
- Phosphorylation
- Platelet Aggregation Inhibitors -- pharmacology
- Promoter Regions, Genetic -- genetics
- Protein Phosphatase 2
- Protein Processing, Post-Translational
- Reduced Folate Carrier Protein
- Sp1 Transcription Factor -- metabolism
- Thionucleotides -- pharmacology
- Transcription, Genetic
- Transfection
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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