Loss of Sp1 function via inhibitory phosphorylation in antifolate-resistant human leukemia cells with down-regulation of the reduced folate carrier.

Stark, Michal

Loss of Sp1 function via inhibitory phosphorylation in antifolate-resistant human leukemia cells with down-regulation of the reduced folate carrier. [electronic resource] - Blood Jan 2006 - 708-15 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0006-4971

10.1182/blood-2005-07-2743 doi


1-Methyl-3-isobutylxanthine--pharmacology
Alkaline Phosphatase--metabolism
Binding Sites
Cyclic AMP--metabolism
Cyclic AMP-Dependent Protein Kinases--metabolism
Cyclic GMP--analogs & derivatives
Down-Regulation
Drug Resistance, Neoplasm
Electrophoretic Mobility Shift Assay
Enzyme Inhibitors--pharmacology
Folic Acid Antagonists--pharmacology
GC Rich Sequence
Humans
Leukemia, T-Cell--drug therapy
Luciferases--metabolism
Membrane Transport Proteins--genetics
Nuclear Proteins
Okadaic Acid--pharmacology
Phosphodiesterase Inhibitors--pharmacology
Phosphoprotein Phosphatases--antagonists & inhibitors
Phosphorylation
Platelet Aggregation Inhibitors--pharmacology
Promoter Regions, Genetic--genetics
Protein Phosphatase 2
Protein Processing, Post-Translational
Reduced Folate Carrier Protein
Sp1 Transcription Factor--metabolism
Thionucleotides--pharmacology
Transcription, Genetic
Transfection
Tumor Cells, Cultured