Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. [electronic resource]
Producer: 20060112Description: 2251-7 p. digitalISSN:- 1524-4628
- 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine -- analogs & derivatives
- Amides -- pharmacology
- Analysis of Variance
- Animals
- Antihypertensive Agents -- pharmacology
- Aorta -- cytology
- Blotting, Northern
- Blotting, Western
- Brain Ischemia -- pathology
- Cattle
- Cell Line
- Cells, Cultured
- Cerebrovascular Circulation
- Dose-Response Relationship, Drug
- Down-Regulation
- Endothelium, Vascular -- cytology
- Enzyme Inhibitors -- pharmacology
- Humans
- Hypoxia
- Infarction, Middle Cerebral Artery
- Intracellular Signaling Peptides and Proteins
- Mice
- Mice, Inbred C57BL
- Neuroprotective Agents -- pharmacology
- Nitric Oxide -- metabolism
- Nitric Oxide Synthase -- metabolism
- Nitric Oxide Synthase Type III -- biosynthesis
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Pyridines -- pharmacology
- RNA, Messenger -- metabolism
- Regional Blood Flow
- Stroke -- prevention & control
- Time Factors
- Umbilical Veins -- cytology
- Up-Regulation
- rho-Associated Kinases
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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