Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.

Rikitake, Yoshiyuki

Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. [electronic resource] - Stroke Oct 2005 - 2251-7 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

1524-4628

10.1161/01.STR.0000181077.84981.11 doi


1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine--analogs & derivatives
Amides--pharmacology
Analysis of Variance
Animals
Antihypertensive Agents--pharmacology
Aorta--cytology
Blotting, Northern
Blotting, Western
Brain Ischemia--pathology
Cattle
Cell Line
Cells, Cultured
Cerebrovascular Circulation
Dose-Response Relationship, Drug
Down-Regulation
Endothelium, Vascular--cytology
Enzyme Inhibitors--pharmacology
Humans
Hypoxia
Infarction, Middle Cerebral Artery
Intracellular Signaling Peptides and Proteins
Mice
Mice, Inbred C57BL
Neuroprotective Agents--pharmacology
Nitric Oxide--metabolism
Nitric Oxide Synthase--metabolism
Nitric Oxide Synthase Type III--biosynthesis
Protein Serine-Threonine Kinases--antagonists & inhibitors
Pyridines--pharmacology
RNA, Messenger--metabolism
Regional Blood Flow
Stroke--prevention & control
Time Factors
Umbilical Veins--cytology
Up-Regulation
rho-Associated Kinases