Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation. [electronic resource]
Producer: 20051213Description: 35217-27 p. digitalISSN:- 0021-9258
- Antineoplastic Agents -- pharmacology
- Apoptosis
- Benzenesulfonates -- pharmacology
- Caspase 3
- Caspase 7
- Caspase 9
- Caspases -- biosynthesis
- Cell Line, Tumor
- Chromatography
- Dose-Response Relationship, Drug
- Down-Regulation
- Enzyme Inhibitors -- pharmacology
- Genes, Reporter
- Humans
- Immunoblotting
- Immunoprecipitation
- Jurkat Cells
- K562 Cells
- Leukemia -- drug therapy
- Myeloid Cell Leukemia Sequence 1 Protein
- Neoplasm Proteins -- biosynthesis
- Niacinamide -- analogs & derivatives
- Phenylurea Compounds
- Phosphorylation
- Promoter Regions, Genetic
- Protein Biosynthesis
- Proto-Oncogene Proteins c-bcl-2 -- biosynthesis
- Pyridines -- pharmacology
- RNA, Messenger -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Sorafenib
- Subcellular Fractions -- metabolism
- Time Factors
- Transcription, Genetic
- Transfection
- U937 Cells
- Ubiquitin -- chemistry
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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