Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation.

Rahmani, Mohamed

Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation. [electronic resource] - The Journal of biological chemistry Oct 2005 - 35217-27 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

0021-9258

10.1074/jbc.M506551200 doi


Antineoplastic Agents--pharmacology
Apoptosis
Benzenesulfonates--pharmacology
Caspase 3
Caspase 7
Caspase 9
Caspases--biosynthesis
Cell Line, Tumor
Chromatography
Dose-Response Relationship, Drug
Down-Regulation
Enzyme Inhibitors--pharmacology
Genes, Reporter
Humans
Immunoblotting
Immunoprecipitation
Jurkat Cells
K562 Cells
Leukemia--drug therapy
Myeloid Cell Leukemia Sequence 1 Protein
Neoplasm Proteins--biosynthesis
Niacinamide--analogs & derivatives
Phenylurea Compounds
Phosphorylation
Promoter Regions, Genetic
Protein Biosynthesis
Proto-Oncogene Proteins c-bcl-2--biosynthesis
Pyridines--pharmacology
RNA, Messenger--metabolism
Reverse Transcriptase Polymerase Chain Reaction
Sorafenib
Subcellular Fractions--metabolism
Time Factors
Transcription, Genetic
Transfection
U937 Cells
Ubiquitin--chemistry