Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107. [electronic resource]
Producer: 20050920Description: 10970-5 p. digitalISSN:- 0027-8424
- Allosteric Site -- genetics
- Amino Acid Substitution
- Animals
- Arthritis, Experimental -- genetics
- Base Sequence
- Cell Line
- DNA -- genetics
- Humans
- In Vitro Techniques
- Male
- Mice
- Mice, Inbred DBA
- Models, Molecular
- Mutagenesis, Site-Directed
- NF-kappa B -- metabolism
- Protein Conformation
- Receptors, Tumor Necrosis Factor, Type I -- antagonists & inhibitors
- Signal Transduction
- Tryptophan -- chemistry
- Tumor Necrosis Factor-alpha -- metabolism
- p38 Mitogen-Activated Protein Kinases -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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