Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107.
Murali, Ramachandran
Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Aug 2005 - 10970-5 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0027-8424
10.1073/pnas.0504301102 doi
Allosteric Site--genetics
Amino Acid Substitution
Animals
Arthritis, Experimental--genetics
Base Sequence
Cell Line
DNA--genetics
Humans
In Vitro Techniques
Male
Mice
Mice, Inbred DBA
Models, Molecular
Mutagenesis, Site-Directed
NF-kappa B--metabolism
Protein Conformation
Receptors, Tumor Necrosis Factor, Type I--antagonists & inhibitors
Signal Transduction
Tryptophan--chemistry
Tumor Necrosis Factor-alpha--metabolism
p38 Mitogen-Activated Protein Kinases--metabolism
Disabling TNF receptor signaling by induced conformational perturbation of tryptophan-107. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Aug 2005 - 10970-5 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0027-8424
10.1073/pnas.0504301102 doi
Allosteric Site--genetics
Amino Acid Substitution
Animals
Arthritis, Experimental--genetics
Base Sequence
Cell Line
DNA--genetics
Humans
In Vitro Techniques
Male
Mice
Mice, Inbred DBA
Models, Molecular
Mutagenesis, Site-Directed
NF-kappa B--metabolism
Protein Conformation
Receptors, Tumor Necrosis Factor, Type I--antagonists & inhibitors
Signal Transduction
Tryptophan--chemistry
Tumor Necrosis Factor-alpha--metabolism
p38 Mitogen-Activated Protein Kinases--metabolism