Increased anticancer activity of the thymidylate synthase inhibitor BGC9331 combined with the topoisomerase I inhibitor SN-38 in human colorectal and breast cancer cells: induction of apoptosis and ROCK cleavage through caspase-3-dependent and -independent mechanisms. [electronic resource]
Producer: 20051223Description: 553-61 p. digitalISSN:- 1019-6439
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Breast Neoplasms -- metabolism
- Camptothecin -- analogs & derivatives
- Caspase 3
- Caspase Inhibitors
- Caspases -- metabolism
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Colorectal Neoplasms -- metabolism
- Cysteine Proteinase Inhibitors -- pharmacology
- DNA Topoisomerases, Type I -- metabolism
- Dose-Response Relationship, Drug
- Drug Synergism
- Enzyme Inhibitors -- pharmacology
- Fluorouracil -- pharmacology
- Folic Acid Antagonists -- pharmacology
- Glutamates -- pharmacology
- Guanine -- analogs & derivatives
- HT29 Cells
- Humans
- Intracellular Signaling Peptides and Proteins
- Irinotecan
- Oligopeptides -- pharmacology
- Organoplatinum Compounds -- pharmacology
- Oxaliplatin
- Pemetrexed
- Protein Serine-Threonine Kinases -- metabolism
- Quinazolines -- pharmacology
- Thymidylate Synthase -- antagonists & inhibitors
- Time Factors
- Topoisomerase I Inhibitors
- rho-Associated Kinases
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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