Increased anticancer activity of the thymidylate synthase inhibitor BGC9331 combined with the topoisomerase I inhibitor SN-38 in human colorectal and breast cancer cells: induction of apoptosis and ROCK cleavage through caspase-3-dependent and -independent mechanisms.
Coudray, Anne-Marie
Increased anticancer activity of the thymidylate synthase inhibitor BGC9331 combined with the topoisomerase I inhibitor SN-38 in human colorectal and breast cancer cells: induction of apoptosis and ROCK cleavage through caspase-3-dependent and -independent mechanisms. [electronic resource] - International journal of oncology Aug 2005 - 553-61 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1019-6439
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Breast Neoplasms--metabolism
Camptothecin--analogs & derivatives
Caspase 3
Caspase Inhibitors
Caspases--metabolism
Cell Cycle--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Colorectal Neoplasms--metabolism
Cysteine Proteinase Inhibitors--pharmacology
DNA Topoisomerases, Type I--metabolism
Dose-Response Relationship, Drug
Drug Synergism
Enzyme Inhibitors--pharmacology
Fluorouracil--pharmacology
Folic Acid Antagonists--pharmacology
Glutamates--pharmacology
Guanine--analogs & derivatives
HT29 Cells
Humans
Intracellular Signaling Peptides and Proteins
Irinotecan
Oligopeptides--pharmacology
Organoplatinum Compounds--pharmacology
Oxaliplatin
Pemetrexed
Protein Serine-Threonine Kinases--metabolism
Quinazolines--pharmacology
Thymidylate Synthase--antagonists & inhibitors
Time Factors
Topoisomerase I Inhibitors
rho-Associated Kinases
Increased anticancer activity of the thymidylate synthase inhibitor BGC9331 combined with the topoisomerase I inhibitor SN-38 in human colorectal and breast cancer cells: induction of apoptosis and ROCK cleavage through caspase-3-dependent and -independent mechanisms. [electronic resource] - International journal of oncology Aug 2005 - 553-61 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
1019-6439
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Breast Neoplasms--metabolism
Camptothecin--analogs & derivatives
Caspase 3
Caspase Inhibitors
Caspases--metabolism
Cell Cycle--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Colorectal Neoplasms--metabolism
Cysteine Proteinase Inhibitors--pharmacology
DNA Topoisomerases, Type I--metabolism
Dose-Response Relationship, Drug
Drug Synergism
Enzyme Inhibitors--pharmacology
Fluorouracil--pharmacology
Folic Acid Antagonists--pharmacology
Glutamates--pharmacology
Guanine--analogs & derivatives
HT29 Cells
Humans
Intracellular Signaling Peptides and Proteins
Irinotecan
Oligopeptides--pharmacology
Organoplatinum Compounds--pharmacology
Oxaliplatin
Pemetrexed
Protein Serine-Threonine Kinases--metabolism
Quinazolines--pharmacology
Thymidylate Synthase--antagonists & inhibitors
Time Factors
Topoisomerase I Inhibitors
rho-Associated Kinases