Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an alphaIIbbeta3- and aggregation-independent manner. [electronic resource]
Producer: 20051107Description: 2750-6 p. digitalISSN:- 0006-4971
- Adenosine Triphosphate -- metabolism
- Animals
- Blood Platelets -- drug effects
- CD36 Antigens -- metabolism
- Crotalid Venoms -- pharmacology
- Enzyme Precursors -- deficiency
- Intracellular Signaling Peptides and Proteins
- Mice
- Mice, Knockout
- Phosphatidylinositol 3-Kinases -- metabolism
- Phospholipase C gamma
- Platelet Aggregation -- drug effects
- Platelet Glycoprotein GPIIb-IIIa Complex -- metabolism
- Platelet Glycoprotein GPIb-IX Complex -- metabolism
- Protein Kinase C -- metabolism
- Protein Kinase Inhibitors -- pharmacology
- Protein-Tyrosine Kinases -- deficiency
- Proto-Oncogene Proteins pp60(c-src) -- antagonists & inhibitors
- Receptors, Fc -- metabolism
- Signal Transduction -- drug effects
- Syk Kinase
- Thromboxane A2 -- metabolism
- Type C Phospholipases -- deficiency
- src-Family Kinases -- metabolism
- von Willebrand Factor -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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