Chemokine-induced recruitment of genetically modified bone marrow cells into the CNS of GM1-gangliosidosis mice corrects neuronal pathology. [electronic resource]
Producer: 20051128Description: 2259-68 p. digitalISSN:- 0006-4971
- Animals
- Apoptosis
- Bone Marrow Cells -- cytology
- Brain -- metabolism
- Calcium -- metabolism
- Cell Movement
- Cell Proliferation
- Cell Transplantation
- Central Nervous System -- metabolism
- Chemokine CCL3
- Chemokine CCL4
- Chemokine CXCL12
- Chemokines -- metabolism
- Chemokines, CXC -- metabolism
- Chromatography, Thin Layer
- Down-Regulation
- Endoplasmic Reticulum -- metabolism
- Enzyme-Linked Immunosorbent Assay
- Gangliosidosis, GM1 -- genetics
- Genetic Therapy -- methods
- Genetic Vectors
- Green Fluorescent Proteins -- metabolism
- Humans
- Immunohistochemistry
- Inflammation
- Lysosomes -- enzymology
- Macrophage Inflammatory Proteins -- metabolism
- Mice
- Mice, Transgenic
- Microscopy, Fluorescence
- Neurodegenerative Diseases -- pathology
- Neurons -- pathology
- Protein Folding
- RNA -- chemistry
- Reverse Transcriptase Polymerase Chain Reaction
- Ribonucleases -- metabolism
- Time Factors
- Up-Regulation
- beta-Galactosidase -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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