Chemokine-induced recruitment of genetically modified bone marrow cells into the CNS of GM1-gangliosidosis mice corrects neuronal pathology.

Sano, Renata

Chemokine-induced recruitment of genetically modified bone marrow cells into the CNS of GM1-gangliosidosis mice corrects neuronal pathology. [electronic resource] - Blood Oct 2005 - 2259-68 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0006-4971

10.1182/blood-2005-03-1189 doi


Animals
Apoptosis
Bone Marrow Cells--cytology
Brain--metabolism
Calcium--metabolism
Cell Movement
Cell Proliferation
Cell Transplantation
Central Nervous System--metabolism
Chemokine CCL3
Chemokine CCL4
Chemokine CXCL12
Chemokines--metabolism
Chemokines, CXC--metabolism
Chromatography, Thin Layer
Down-Regulation
Endoplasmic Reticulum--metabolism
Enzyme-Linked Immunosorbent Assay
Gangliosidosis, GM1--genetics
Genetic Therapy--methods
Genetic Vectors
Green Fluorescent Proteins--metabolism
Humans
Immunohistochemistry
Inflammation
Lysosomes--enzymology
Macrophage Inflammatory Proteins--metabolism
Mice
Mice, Transgenic
Microscopy, Fluorescence
Neurodegenerative Diseases--pathology
Neurons--pathology
Protein Folding
RNA--chemistry
Reverse Transcriptase Polymerase Chain Reaction
Ribonucleases--metabolism
Time Factors
Up-Regulation
beta-Galactosidase--metabolism