The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. [electronic resource]
Producer: 20050516Description: 747-59 p. digitalISSN:- 0092-8674
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Cycle Proteins -- antagonists & inhibitors
- Cell Survival -- drug effects
- Cisplatin -- pharmacology
- Cyclin-Dependent Kinase Inhibitor p21
- DNA Damage -- drug effects
- Drug Synergism
- Everolimus
- Humans
- Mutation
- Polyribosomes -- drug effects
- Protein Biosynthesis -- drug effects
- Protein Kinases -- genetics
- RNA, Small Interfering -- genetics
- Sirolimus -- analogs & derivatives
- TOR Serine-Threonine Kinases
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53 -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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