The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.
Beuvink, Iwan
The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. [electronic resource] - Cell Mar 2005 - 747-59 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0092-8674
10.1016/j.cell.2004.12.040 doi
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Cycle Proteins--antagonists & inhibitors
Cell Survival--drug effects
Cisplatin--pharmacology
Cyclin-Dependent Kinase Inhibitor p21
DNA Damage--drug effects
Drug Synergism
Everolimus
Humans
Mutation
Polyribosomes--drug effects
Protein Biosynthesis--drug effects
Protein Kinases--genetics
RNA, Small Interfering--genetics
Sirolimus--analogs & derivatives
TOR Serine-Threonine Kinases
Tumor Cells, Cultured
Tumor Suppressor Protein p53--genetics
The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. [electronic resource] - Cell Mar 2005 - 747-59 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0092-8674
10.1016/j.cell.2004.12.040 doi
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Cycle Proteins--antagonists & inhibitors
Cell Survival--drug effects
Cisplatin--pharmacology
Cyclin-Dependent Kinase Inhibitor p21
DNA Damage--drug effects
Drug Synergism
Everolimus
Humans
Mutation
Polyribosomes--drug effects
Protein Biosynthesis--drug effects
Protein Kinases--genetics
RNA, Small Interfering--genetics
Sirolimus--analogs & derivatives
TOR Serine-Threonine Kinases
Tumor Cells, Cultured
Tumor Suppressor Protein p53--genetics