Decreased stability and translation of T cell receptor zeta mRNA with an alternatively spliced 3'-untranslated region contribute to zeta chain down-regulation in patients with systemic lupus erythematosus. [electronic resource]
Producer: 20050712Description: 18959-66 p. digitalISSN:- 0021-9258
- 3' Untranslated Regions
- Alternative Splicing
- Animals
- COS Cells
- Cloning, Molecular
- DNA Primers -- chemistry
- Densitometry
- Down-Regulation
- Gene Expression Regulation
- Genes, Reporter
- Humans
- Immunoblotting
- Jurkat Cells
- Luciferases -- metabolism
- Lupus Erythematosus, Systemic -- metabolism
- Membrane Proteins -- chemistry
- Protein Biosynthesis
- Protein Structure, Tertiary
- RNA, Messenger -- metabolism
- Receptors, Antigen, T-Cell -- chemistry
- Reverse Transcriptase Polymerase Chain Reaction
- T-Lymphocytes -- metabolism
- Time Factors
- Transcription, Genetic
- Transfection
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.
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