Decreased stability and translation of T cell receptor zeta mRNA with an alternatively spliced 3'-untranslated region contribute to zeta chain down-regulation in patients with systemic lupus erythematosus.

Chowdhury, Bhabadeb

Decreased stability and translation of T cell receptor zeta mRNA with an alternatively spliced 3'-untranslated region contribute to zeta chain down-regulation in patients with systemic lupus erythematosus. [electronic resource] - The Journal of biological chemistry May 2005 - 18959-66 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.

0021-9258

10.1074/jbc.M501048200 doi


3' Untranslated Regions
Alternative Splicing
Animals
COS Cells
Cloning, Molecular
DNA Primers--chemistry
Densitometry
Down-Regulation
Gene Expression Regulation
Genes, Reporter
Humans
Immunoblotting
Jurkat Cells
Luciferases--metabolism
Lupus Erythematosus, Systemic--metabolism
Membrane Proteins--chemistry
Protein Biosynthesis
Protein Structure, Tertiary
RNA, Messenger--metabolism
Receptors, Antigen, T-Cell--chemistry
Reverse Transcriptase Polymerase Chain Reaction
T-Lymphocytes--metabolism
Time Factors
Transcription, Genetic
Transfection