CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist. [electronic resource]
Producer: 20050405Description: 995-1018 p. digitalISSN:- 0022-2623
- Animals
- Anticonvulsants -- chemical synthesis
- Binding Sites
- Carboxylic Acids -- chemical synthesis
- Cyclic GMP -- biosynthesis
- Glycine -- metabolism
- In Vitro Techniques
- Indoles -- chemical synthesis
- Male
- Mice
- Mice, Inbred DBA
- Models, Molecular
- Neuroprotective Agents -- chemical synthesis
- Phenylacetates -- chemical synthesis
- Quantitative Structure-Activity Relationship
- Radioligand Assay
- Rats
- Rats, Sprague-Dawley
- Receptors, N-Methyl-D-Aspartate -- antagonists & inhibitors
- Seizures -- etiology
- Stereoisomerism
- Stroke -- drug therapy
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Publication Type: Journal Article
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