CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist.

Baron, Bruce M

CoMFA, synthesis, and pharmacological evaluation of (E)-3-(2-carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic acids: 3-[2-(3-aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic acid, a potent selective glycine-site NMDA receptor antagonist. [electronic resource] - Journal of medicinal chemistry Feb 2005 - 995-1018 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm0491849 doi


Animals
Anticonvulsants--chemical synthesis
Binding Sites
Carboxylic Acids--chemical synthesis
Cyclic GMP--biosynthesis
Glycine--metabolism
In Vitro Techniques
Indoles--chemical synthesis
Male
Mice
Mice, Inbred DBA
Models, Molecular
Neuroprotective Agents--chemical synthesis
Phenylacetates--chemical synthesis
Quantitative Structure-Activity Relationship
Radioligand Assay
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate--antagonists & inhibitors
Seizures--etiology
Stereoisomerism
Stroke--drug therapy