Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide. [electronic resource]
Producer: 20050421Description: 1221-7 p. digitalISSN:- 1535-7163
- Antineoplastic Agents -- pharmacology
- Catalytic Domain
- Cell Line, Tumor
- Checkpoint Kinase 1
- Crystallography, X-Ray
- Cysteine -- chemistry
- DNA Damage
- Dose-Response Relationship, Drug
- G2 Phase
- Glutamine -- chemistry
- Glycogen Synthase Kinase 3 -- metabolism
- Glycogen Synthase Kinase 3 beta
- Humans
- Imidazoles -- pharmacology
- Indoles -- antagonists & inhibitors
- Inhibitory Concentration 50
- Maleimides -- antagonists & inhibitors
- Models, Chemical
- Models, Molecular
- Nitrogen -- chemistry
- Phenotype
- Protein Binding
- Protein Kinase C -- metabolism
- Protein Kinase C beta
- Protein Kinases -- metabolism
- Protein Structure, Tertiary
- Time Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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