Electron spin resonance spectroscopy reveals alpha-phenyl-N-tert-butylnitrone spin-traps free radicals in rat striatum and prevents haloperidol-induced vacuous chewing movements in the rat model of human tardive dyskinesia. [electronic resource]
Producer: 20050131Description: 156-63 p. digitalISSN:- 0887-4476
- Analysis of Variance
- Animals
- Antipsychotic Agents -- toxicity
- Apomorphine -- pharmacology
- Behavior, Animal
- Binding Sites
- Corpus Striatum -- drug effects
- Cyclic N-Oxides
- Disease Models, Animal
- Dopamine Agonists -- pharmacology
- Drug Interactions
- Dyskinesia, Drug-Induced -- complications
- Electron Spin Resonance Spectroscopy
- Haloperidol -- toxicity
- Humans
- Male
- Mastication -- drug effects
- Motor Activity -- drug effects
- Movement Disorders -- etiology
- Neuroprotective Agents -- therapeutic use
- Nitrogen Oxides -- therapeutic use
- Rats
- Rats, Sprague-Dawley
- Reactive Oxygen Species -- metabolism
- Receptors, Dopamine D2 -- physiology
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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