Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19. [electronic resource]
Producer: 20050408Description: 1462-7 p. digitalISSN:- 0090-9556
- Antibodies, Monoclonal -- pharmacology
- Aryl Hydrocarbon Hydroxylases -- antagonists & inhibitors
- Biotransformation
- Cytochrome P-450 CYP2C19
- Enzyme Inhibitors -- pharmacology
- HIV Protease Inhibitors -- pharmacokinetics
- Humans
- Hydroxylation
- In Vitro Techniques
- Kinetics
- Microsomes, Liver -- metabolism
- Mixed Function Oxygenases -- antagonists & inhibitors
- Nelfinavir -- analogs & derivatives
- Omeprazole -- pharmacology
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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