Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19.

Hirani, Vandana N

Conversion of the HIV protease inhibitor nelfinavir to a bioactive metabolite by human liver CYP2C19. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Dec 2004 - 1462-7 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0090-9556

10.1124/dmd.104.001743 doi


Antibodies, Monoclonal--pharmacology
Aryl Hydrocarbon Hydroxylases--antagonists & inhibitors
Biotransformation
Cytochrome P-450 CYP2C19
Enzyme Inhibitors--pharmacology
HIV Protease Inhibitors--pharmacokinetics
Humans
Hydroxylation
In Vitro Techniques
Kinetics
Microsomes, Liver--metabolism
Mixed Function Oxygenases--antagonists & inhibitors
Nelfinavir--analogs & derivatives
Omeprazole--pharmacology