Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid. [electronic resource]
Producer: 20050324Description: 1702-11 p. digitalISSN:- 0026-895X
- 20-Hydroxysteroid Dehydrogenases -- metabolism
- Alcohol Oxidoreductases -- metabolism
- Aldehyde Reductase
- Aldo-Keto Reductases
- Estrogen Receptor Modulators -- pharmacology
- Humans
- Isoenzymes -- metabolism
- Ketosteroids -- pharmacokinetics
- Kinetics
- Norpregnenes -- pharmacokinetics
- Osteoporosis -- prevention & control
- Recombinant Proteins -- metabolism
- Substrate Specificity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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