Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid.

Steckelbroeck, Stephan

Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid. [electronic resource] - Molecular pharmacology Dec 2004 - 1702-11 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0026-895X

10.1124/mol.104.004515 doi


20-Hydroxysteroid Dehydrogenases--metabolism
Alcohol Oxidoreductases--metabolism
Aldehyde Reductase
Aldo-Keto Reductases
Estrogen Receptor Modulators--pharmacology
Humans
Isoenzymes--metabolism
Ketosteroids--pharmacokinetics
Kinetics
Norpregnenes--pharmacokinetics
Osteoporosis--prevention & control
Recombinant Proteins--metabolism
Substrate Specificity