A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity. [electronic resource]
Producer: 20041124Description: 42516-27 p. digitalISSN:- 0021-9258
- Actins -- metabolism
- Animals
- Apoptosis
- Asparagine -- chemistry
- Aspartic Acid -- chemistry
- Becaplermin
- Binding Sites
- COS Cells
- Cells, Cultured
- Dose-Response Relationship, Drug
- Enzyme Activation
- Fibroblasts -- metabolism
- Flow Cytometry
- Genetic Vectors
- Humans
- Kinetics
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3 -- metabolism
- Mutation
- NIH 3T3 Cells
- Phosphatidylinositol 3-Kinases -- metabolism
- Platelet-Derived Growth Factor -- metabolism
- Point Mutation
- Protein Serine-Threonine Kinases -- metabolism
- Protein Structure, Tertiary
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins c-sis
- Receptor, Platelet-Derived Growth Factor beta -- genetics
- Signal Transduction
- Substrate Specificity
- Time Factors
- Tyrosine -- chemistry
- Up-Regulation
- Wound Healing
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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