A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity.

Chiara, Federica

A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity. [electronic resource] - The Journal of biological chemistry Oct 2004 - 42516-27 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M406051200 doi


Actins--metabolism
Animals
Apoptosis
Asparagine--chemistry
Aspartic Acid--chemistry
Becaplermin
Binding Sites
COS Cells
Cells, Cultured
Dose-Response Relationship, Drug
Enzyme Activation
Fibroblasts--metabolism
Flow Cytometry
Genetic Vectors
Humans
Kinetics
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Mitogen-Activated Protein Kinase 1--metabolism
Mitogen-Activated Protein Kinase 3--metabolism
Mutation
NIH 3T3 Cells
Phosphatidylinositol 3-Kinases--metabolism
Platelet-Derived Growth Factor--metabolism
Point Mutation
Protein Serine-Threonine Kinases--metabolism
Protein Structure, Tertiary
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-akt
Proto-Oncogene Proteins c-sis
Receptor, Platelet-Derived Growth Factor beta--genetics
Signal Transduction
Substrate Specificity
Time Factors
Tyrosine--chemistry
Up-Regulation
Wound Healing