Leptomycin B-induced apoptosis is mediated through caspase activation and down-regulation of Mcl-1 and XIAP expression, but not through the generation of ROS in U937 leukemia cells. [electronic resource]
Producer: 20040802Description: 263-74 p. digitalISSN:- 0006-2952
- Antibiotics, Antineoplastic -- pharmacology
- Apoptosis
- Caspases -- metabolism
- Cell Survival
- Down-Regulation
- Enzyme Activation
- Fatty Acids, Unsaturated -- chemistry
- Gene Expression
- Humans
- Leukemia -- pathology
- Myeloid Cell Leukemia Sequence 1 Protein
- Neoplasm Proteins -- metabolism
- Proteins -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Reactive Oxygen Species -- metabolism
- U937 Cells
- X-Linked Inhibitor of Apoptosis Protein
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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