Leptomycin B-induced apoptosis is mediated through caspase activation and down-regulation of Mcl-1 and XIAP expression, but not through the generation of ROS in U937 leukemia cells.
Jang, Byeong-Churl
Leptomycin B-induced apoptosis is mediated through caspase activation and down-regulation of Mcl-1 and XIAP expression, but not through the generation of ROS in U937 leukemia cells. [electronic resource] - Biochemical pharmacology Jul 2004 - 263-74 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0006-2952
10.1016/j.bcp.2004.03.007 doi
Antibiotics, Antineoplastic--pharmacology
Apoptosis
Caspases--metabolism
Cell Survival
Down-Regulation
Enzyme Activation
Fatty Acids, Unsaturated--chemistry
Gene Expression
Humans
Leukemia--pathology
Myeloid Cell Leukemia Sequence 1 Protein
Neoplasm Proteins--metabolism
Proteins--metabolism
Proto-Oncogene Proteins c-bcl-2--metabolism
Reactive Oxygen Species--metabolism
U937 Cells
X-Linked Inhibitor of Apoptosis Protein
Leptomycin B-induced apoptosis is mediated through caspase activation and down-regulation of Mcl-1 and XIAP expression, but not through the generation of ROS in U937 leukemia cells. [electronic resource] - Biochemical pharmacology Jul 2004 - 263-74 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0006-2952
10.1016/j.bcp.2004.03.007 doi
Antibiotics, Antineoplastic--pharmacology
Apoptosis
Caspases--metabolism
Cell Survival
Down-Regulation
Enzyme Activation
Fatty Acids, Unsaturated--chemistry
Gene Expression
Humans
Leukemia--pathology
Myeloid Cell Leukemia Sequence 1 Protein
Neoplasm Proteins--metabolism
Proteins--metabolism
Proto-Oncogene Proteins c-bcl-2--metabolism
Reactive Oxygen Species--metabolism
U937 Cells
X-Linked Inhibitor of Apoptosis Protein