PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis. [electronic resource]
Producer: 20040628Description: 51-61 p. digitalISSN:- 0169-328X
- Animals
- Animals, Newborn
- Apoptosis -- physiology
- Brain -- cytology
- Carrier Proteins -- metabolism
- Chaperonin 60 -- metabolism
- Chromones -- pharmacology
- Cytochromes c -- metabolism
- Cytosol -- metabolism
- DNA Fragmentation -- physiology
- Enzyme Inhibitors -- pharmacology
- Enzyme-Linked Immunosorbent Assay -- methods
- Fluorescent Antibody Technique -- methods
- Hypoxia -- enzymology
- In Situ Nick-End Labeling -- methods
- In Vitro Techniques
- Magnetic Resonance Imaging -- methods
- Mitochondria -- drug effects
- Morpholines -- pharmacology
- Neural Inhibition -- drug effects
- Neurons -- drug effects
- Phosphoinositide-3 Kinase Inhibitors
- Phosphorus Isotopes
- Phosphorylation
- Protein Serine-Threonine Kinases
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt
- Rats
- Rats, Sprague-Dawley
- Serine -- metabolism
- Staining and Labeling -- methods
- Time Factors
- bcl-Associated Death Protein
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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