PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis.
Hirai, Kiyoshi
PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis. [electronic resource] - Brain research. Molecular brain research Apr 2004 - 51-61 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0169-328X
10.1016/j.molbrainres.2004.02.009 doi
Animals
Animals, Newborn
Apoptosis--physiology
Brain--cytology
Carrier Proteins--metabolism
Chaperonin 60--metabolism
Chromones--pharmacology
Cytochromes c--metabolism
Cytosol--metabolism
DNA Fragmentation--physiology
Enzyme Inhibitors--pharmacology
Enzyme-Linked Immunosorbent Assay--methods
Fluorescent Antibody Technique--methods
Hypoxia--enzymology
In Situ Nick-End Labeling--methods
In Vitro Techniques
Magnetic Resonance Imaging--methods
Mitochondria--drug effects
Morpholines--pharmacology
Neural Inhibition--drug effects
Neurons--drug effects
Phosphoinositide-3 Kinase Inhibitors
Phosphorus Isotopes
Phosphorylation
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-akt
Rats
Rats, Sprague-Dawley
Serine--metabolism
Staining and Labeling--methods
Time Factors
bcl-Associated Death Protein
PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis. [electronic resource] - Brain research. Molecular brain research Apr 2004 - 51-61 p. digital
Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
0169-328X
10.1016/j.molbrainres.2004.02.009 doi
Animals
Animals, Newborn
Apoptosis--physiology
Brain--cytology
Carrier Proteins--metabolism
Chaperonin 60--metabolism
Chromones--pharmacology
Cytochromes c--metabolism
Cytosol--metabolism
DNA Fragmentation--physiology
Enzyme Inhibitors--pharmacology
Enzyme-Linked Immunosorbent Assay--methods
Fluorescent Antibody Technique--methods
Hypoxia--enzymology
In Situ Nick-End Labeling--methods
In Vitro Techniques
Magnetic Resonance Imaging--methods
Mitochondria--drug effects
Morpholines--pharmacology
Neural Inhibition--drug effects
Neurons--drug effects
Phosphoinositide-3 Kinase Inhibitors
Phosphorus Isotopes
Phosphorylation
Protein Serine-Threonine Kinases
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-akt
Rats
Rats, Sprague-Dawley
Serine--metabolism
Staining and Labeling--methods
Time Factors
bcl-Associated Death Protein