CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. [electronic resource]
Producer: 20040813Description: 26991-7007 p. digitalISSN:- 0021-9258
- Amides -- pharmacology
- Amiloride -- analogs & derivatives
- Animals
- Breast Neoplasms -- enzymology
- Cathepsin B -- metabolism
- Caveolin 1
- Caveolins -- metabolism
- Cell Line, Tumor
- Endosomes -- metabolism
- Enzyme Inhibitors -- pharmacology
- Humans
- Hyaluronan Receptors -- chemistry
- Hyaluronic Acid -- metabolism
- Hyaluronoglucosaminidase -- genetics
- Hydrogen-Ion Concentration
- Immunoglobulin G -- pharmacology
- Intracellular Signaling Peptides and Proteins
- Lysosomes -- metabolism
- Membrane Microdomains -- chemistry
- Membrane Proteins -- metabolism
- Neoplasm Invasiveness
- Phosphorylation
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Pyridines -- pharmacology
- RNA, Small Interfering -- pharmacology
- Rats
- Sodium-Hydrogen Exchangers -- antagonists & inhibitors
- rho-Associated Kinases
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Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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