CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion.

Bourguignon, Lilly Y W

CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. [electronic resource] - The Journal of biological chemistry Jun 2004 - 26991-7007 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

0021-9258

10.1074/jbc.M311838200 doi


Amides--pharmacology
Amiloride--analogs & derivatives
Animals
Breast Neoplasms--enzymology
Cathepsin B--metabolism
Caveolin 1
Caveolins--metabolism
Cell Line, Tumor
Endosomes--metabolism
Enzyme Inhibitors--pharmacology
Humans
Hyaluronan Receptors--chemistry
Hyaluronic Acid--metabolism
Hyaluronoglucosaminidase--genetics
Hydrogen-Ion Concentration
Immunoglobulin G--pharmacology
Intracellular Signaling Peptides and Proteins
Lysosomes--metabolism
Membrane Microdomains--chemistry
Membrane Proteins--metabolism
Neoplasm Invasiveness
Phosphorylation
Protein Serine-Threonine Kinases--antagonists & inhibitors
Pyridines--pharmacology
RNA, Small Interfering--pharmacology
Rats
Sodium-Hydrogen Exchangers--antagonists & inhibitors
rho-Associated Kinases