Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. [electronic resource]
Producer: 20040910Description: 1459-65 p. digitalISSN:- 0143-3334
- Animals
- Anticarcinogenic Agents -- pharmacology
- Apoptosis
- Cell Division
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins -- biosynthesis
- DNA Damage
- Dimerization
- Epidermis -- metabolism
- Female
- Immunohistochemistry
- In Situ Nick-End Labeling
- Mice
- Mice, Hairless
- Models, Biological
- Proliferating Cell Nuclear Antigen
- Pyrimidine Dimers -- chemistry
- Silybin
- Silymarin -- pharmacology
- Skin -- drug effects
- Skin Neoplasms -- prevention & control
- Time Factors
- Tumor Suppressor Protein p53 -- biosynthesis
- Ultraviolet Rays
- Up-Regulation
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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