Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis.
Dhanalakshmi, Sivanandhan
Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. [electronic resource] - Carcinogenesis Aug 2004 - 1459-65 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0143-3334
10.1093/carcin/bgh152 doi
Animals
Anticarcinogenic Agents--pharmacology
Apoptosis
Cell Division
Cyclin-Dependent Kinase Inhibitor p21
Cyclins--biosynthesis
DNA Damage
Dimerization
Epidermis--metabolism
Female
Immunohistochemistry
In Situ Nick-End Labeling
Mice
Mice, Hairless
Models, Biological
Proliferating Cell Nuclear Antigen
Pyrimidine Dimers--chemistry
Silybin
Silymarin--pharmacology
Skin--drug effects
Skin Neoplasms--prevention & control
Time Factors
Tumor Suppressor Protein p53--biosynthesis
Ultraviolet Rays
Up-Regulation
Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. [electronic resource] - Carcinogenesis Aug 2004 - 1459-65 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
0143-3334
10.1093/carcin/bgh152 doi
Animals
Anticarcinogenic Agents--pharmacology
Apoptosis
Cell Division
Cyclin-Dependent Kinase Inhibitor p21
Cyclins--biosynthesis
DNA Damage
Dimerization
Epidermis--metabolism
Female
Immunohistochemistry
In Situ Nick-End Labeling
Mice
Mice, Hairless
Models, Biological
Proliferating Cell Nuclear Antigen
Pyrimidine Dimers--chemistry
Silybin
Silymarin--pharmacology
Skin--drug effects
Skin Neoplasms--prevention & control
Time Factors
Tumor Suppressor Protein p53--biosynthesis
Ultraviolet Rays
Up-Regulation