Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1. [electronic resource]
Producer: 20040630Description: 22057-65 p. digitalISSN:- 0021-9258
- Amino Acid Motifs
- Anilides -- pharmacology
- Binding Sites
- Blotting, Western
- Cell Division
- Cell Nucleus -- metabolism
- Chromans -- pharmacology
- DNA, Complementary -- metabolism
- DNA-Binding Proteins -- metabolism
- Dose-Response Relationship, Drug
- Early Growth Response Protein 1
- Fibroblasts -- metabolism
- Genes, Dominant
- Genes, Reporter
- Humans
- Immediate-Early Proteins -- metabolism
- Immunologic Factors -- pharmacology
- Inflammation
- Interleukin-1 -- metabolism
- Intramolecular Oxidoreductases -- biosynthesis
- Ligands
- Peroxisome Proliferators -- pharmacology
- Plasmids -- metabolism
- Promoter Regions, Genetic
- Prostaglandin D2 -- analogs & derivatives
- Prostaglandin-E Synthases
- Protein Binding
- Pyrimidines -- pharmacology
- RNA -- metabolism
- Receptors, Cytoplasmic and Nuclear -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Synovial Membrane -- cytology
- Thiazolidinediones -- pharmacology
- Time Factors
- Transcription Factors -- metabolism
- Transcription, Genetic
- Transfection
- Troglitazone
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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