Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1.

Cheng, Saranette

Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1. [electronic resource] - The Journal of biological chemistry May 2004 - 22057-65 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M402828200 doi


Amino Acid Motifs
Anilides--pharmacology
Binding Sites
Blotting, Western
Cell Division
Cell Nucleus--metabolism
Chromans--pharmacology
DNA, Complementary--metabolism
DNA-Binding Proteins--metabolism
Dose-Response Relationship, Drug
Early Growth Response Protein 1
Fibroblasts--metabolism
Genes, Dominant
Genes, Reporter
Humans
Immediate-Early Proteins--metabolism
Immunologic Factors--pharmacology
Inflammation
Interleukin-1--metabolism
Intramolecular Oxidoreductases--biosynthesis
Ligands
Peroxisome Proliferators--pharmacology
Plasmids--metabolism
Promoter Regions, Genetic
Prostaglandin D2--analogs & derivatives
Prostaglandin-E Synthases
Protein Binding
Pyrimidines--pharmacology
RNA--metabolism
Receptors, Cytoplasmic and Nuclear--metabolism
Reverse Transcriptase Polymerase Chain Reaction
Synovial Membrane--cytology
Thiazolidinediones--pharmacology
Time Factors
Transcription Factors--metabolism
Transcription, Genetic
Transfection
Troglitazone