Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats. [electronic resource]
Producer: 20040504Description: 1637-45 p. digitalISSN:- 1529-2401
- Active Transport, Cell Nucleus -- drug effects
- Analgesics -- pharmacokinetics
- Animals
- Anti-Inflammatory Agents -- pharmacokinetics
- Cells, Cultured
- Cyclooxygenase 2
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Enzyme Inhibitors -- pharmacokinetics
- Formaldehyde
- Humans
- Hyperalgesia -- complications
- I-kappa B Kinase
- Inflammation -- chemically induced
- Injections, Intraperitoneal
- Interleukin-1 -- genetics
- Isoenzymes -- genetics
- Male
- Membrane Proteins
- NF-kappa B -- metabolism
- Neuralgia -- complications
- Pain Measurement -- drug effects
- Prostaglandin-Endoperoxide Synthases -- genetics
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Rats
- Rats, Sprague-Dawley
- Spinal Cord -- drug effects
- Tumor Necrosis Factor-alpha -- genetics
- Up-Regulation -- drug effects
- Zymosan
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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