Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats.

Tegeder, Irmgard

Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats. [electronic resource] - The Journal of neuroscience : the official journal of the Society for Neuroscience Feb 2004 - 1637-45 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1529-2401

10.1523/JNEUROSCI.3118-03.2004 doi


Active Transport, Cell Nucleus--drug effects
Analgesics--pharmacokinetics
Animals
Anti-Inflammatory Agents--pharmacokinetics
Cells, Cultured
Cyclooxygenase 2
Disease Models, Animal
Dose-Response Relationship, Drug
Enzyme Inhibitors--pharmacokinetics
Formaldehyde
Humans
Hyperalgesia--complications
I-kappa B Kinase
Inflammation--chemically induced
Injections, Intraperitoneal
Interleukin-1--genetics
Isoenzymes--genetics
Male
Membrane Proteins
NF-kappa B--metabolism
Neuralgia--complications
Pain Measurement--drug effects
Prostaglandin-Endoperoxide Synthases--genetics
Protein Serine-Threonine Kinases--antagonists & inhibitors
Rats
Rats, Sprague-Dawley
Spinal Cord--drug effects
Tumor Necrosis Factor-alpha--genetics
Up-Regulation--drug effects
Zymosan