Metabolic stability, receptor binding, cAMP generation, insulin secretion and antihyperglycaemic activity of novel N-terminal Glu9-substituted analogues of glucagon-like peptide-1. [electronic resource]
Producer: 20040920Description: 1543-51 p. digitalISSN:- 1431-6730
- Adenosine Deaminase -- metabolism
- Amino Acid Substitution
- Animals
- Binding, Competitive
- Blood Glucose -- drug effects
- Cell Line, Tumor
- Cricetinae
- Cyclic AMP -- metabolism
- Diabetes Mellitus, Type 2 -- drug therapy
- Dipeptidyl Peptidase 4
- Fibroblasts -- metabolism
- Glucagon -- genetics
- Glucagon-Like Peptide 1
- Glucagon-Like Peptide-1 Receptor
- Glucose -- pharmacology
- Glutamine -- chemistry
- Glycoproteins -- metabolism
- Humans
- Hypoglycemic Agents -- metabolism
- Insulin -- blood
- Insulin Secretion
- Islets of Langerhans -- drug effects
- Mice
- Mice, Obese
- Peptide Fragments -- genetics
- Phenylalanine -- chemistry
- Proline -- chemistry
- Protein Precursors -- genetics
- Rats
- Receptors, Glucagon -- metabolism
- Spectrometry, Mass, Electrospray Ionization
- Transformation, Genetic
- Tyrosine -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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